Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment
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چکیده
منابع مشابه
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment
PURPOSE OF REVIEW Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO. RECENT FINDINGS Though the exact molecula...
متن کاملChronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis
BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is a little known inflammatory bone disease occurring primarily in children and adolescents. Delays in referral and diagnosis may lead to prolonged courses of antibiotics with in-patient care, unnecessary radiation exposure from multiple plain radiographs or bone scans and repeated surgery including bone biopsies. Children (aged < 18 ...
متن کاملRecurrent multifocal osteomyelitis (CRMO); effect of neridronate
Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease of unknown etiology. Clinically, the disease is characterized by the insidious onset of local pain and swelling in affected bones. Its course is one of intermittent periods of exacerbation and remission with successive bones affected.CRMO most commonly affects the metaphysis of long bones, especia...
متن کاملRecessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO)
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by psoriasis or inflammatory bowel disease. There are two syndromic forms of CRMO, Majeed syndrome and DIRA, for which the genetic cause is known. However, for the majority of cases of CRMO, the genetic basis is unknow...
متن کاملA proposed treatment scheme for chronic recurrent multifocal osteomyelitis (CRMO): a case series of nine patients
Results The median age of symptom onset was 8,2 years, while the patients were diagnosed to have CRMO at a median of 10 years of age. Eight out of nine patients presented with extremity pain, while five of the patients had back pain on presentation. Eight out of nine patients presented with extremity pain, while five had back pain on presentation. The patients had a median of three lesions at t...
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ژورنال
عنوان ژورنال: Current Osteoporosis Reports
سال: 2017
ISSN: 1544-1873,1544-2241
DOI: 10.1007/s11914-017-0405-9